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The objective of this study is to evaluate the effectiveness of prochlorperazine and the rate of akathisia in children with severe migraine.

The study is a prospective cohort of a convenient sample of patients younger than 18 years old diagnosed with migraine and treated with intravenous prochlorperazine in adjunction with diphenhydramine in the emergency department. The evaluation of pain and akathisia was performed before the treatment and was repeated 60 minutes later and before discharge. A telephone follow-up was completed to assess relapse in pain and presence of akathisia. The effectiveness of prochlorperazine was determined using different outcomes: 50% reduction of pain, pain-free patients, treatment failure, and relapse of pain.

Of the 79 patients included in the study for 25 months, 64 (81%) either met the International Headache Society criteria or had a …