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Dynapenia, the age-related loss of muscle strength without the loss of muscle mass, significantly impacts the physical function and overall quality of life in older adults, thereby decreasing their health span. Skeletal muscle strength loss has been shown to occur earlier and is greater in aging females than males. Furthermore, clinical and preclinical studies have measured associations between skeletal muscle strength loss and the age at which circulating estrogen begins to decline in females. Despite copious years of skeletal muscle research, the molecular mechanisms underlying muscle strength loss in aging females remain poorly understood. Age-related protein phosphorylation changes have been reported in skeletal muscle of males, and protein phosphorylation alterations have been shown in cardiac muscle across age and sex. However, the extent and magnitude of these changes in the skeletal muscle …