作者
Nuria Sanchez Clemente, Manoela Rodrigues, Ana Paula Pascalicchio, Rosa Estela Gazeta, Danila Vedovello, Elizabeth B Brickley, Marcia F De Almeida, Saulo D Passos
发表日期
2019/8/1
期刊
BMJ open
卷号
9
期号
8
页码范围
e027947
出版商
British Medical Journal Publishing Group
简介
Purpose
The Jundiaí Zika Cohort (JZC) is a prospective pregnancy and birth cohort setup in the State of São Paulo, Brazil, to investigate the epidemic of cases of microcephaly and other neurological disorders, presumed to be associated with Zika virus (ZIKV) infection.
Participants
A total of 748 women with high-risk pregnancies were recruited in the period of March 2016 to August 2017.
Findings to date
Baseline sociodemographic and medical data were collected at recruitment from 737 pregnant women. Biological samples (ie, blood, saliva and urine) were collected from 695 of the pregnant women (94.3%), of whom 53 (7.6%) were ZIKV-positive on subsequent testing by reverse transcription polymerase chain reaction (RT-PCR) in urine. Biological sample (ie, blood, saliva, urine and cerebrospinal fluid) were collected within 10 days of birth from 409 (57.4%) of the liveborn infants, of whom 19 (4.6%) were ZIKV …
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NS Clemente, M Rodrigues, AP Pascalicchio… - BMJ open, 2019