作者
H Esmail, RP Lai, CM Graham, T Oni, N Bangani, JM Warwick, Q Said-Hartley, DB Young, CE Barry, A O'Garra, RJ Wilkinson
发表日期
2014
期刊
American Journal of Respiratory and Critical Care Medicine
卷号
189
页码范围
1
出版商
American Thoracic Society
简介
METHODS
The study setting was Khayelitsha, a township of Cape Town with exceptionally high TB and HIV prevalence. 35 asymptomatic adults, HIV-1 infected, anti-retroviral therapy (ART) naïve, CD4> 350/mm3 with evidence of LTBI (by Quantiferon Gold-in-tube (QFGIT)) but no evidence of active TB on chest radiograph or history of TB underwent 18F-FDG-PET/CT before and after preventive TB treatment. A structured report identified TB related PET/CT changes. Blood was drawn for RNA and also from age, sex and CD4 matched, HIV-1 infected, ART naïve controls with active tuberculosis and those that were tuberculin skin test and QFGIT negative, as well as HIV negative controls and HIV-1 infected controls established on ART. Transcriptional signatures were determined by microarray.
RESULTS
For the 35 asymptomatic participants, median CD4 count was 453/mm3, viral load (VL) 10800 copies/mL, age 31 …
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H Esmail, RP Lai, CM Graham, T Oni, N Bangani… - American Journal of Respiratory and Critical Care …, 2014