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This research aims to design, preparation, and characterization of molecularly imprinted polymeric particles embedded-cryogels for the selective removal of potentially genotoxic impurities 2-aminopyridine and 5-amino-2-chloropyridine in model active pharmaceutical ingredients piroxicam and tenoxicam. For this purpose, aminopyridines imprinted poly (hydroxyethyl methacrylate-methacryloylamido benzotriazole-Cu(II)) particles were prepared and embedded into the cryogel structure. The characterization of the prepared composite cryogels was carried out by FT-IR, swelling tests, and SEM analyses. The results confirmed that the target aminopyridines binding increased with increasing initial concentration up to 1.5 mg mL⁻¹ which is a saturation point. The highest binding of potentially genotoxic impurities was obtained at pH 7.0 and the maximum binding capacity values of the prepared cryogels for 2 …