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Metastasis to the spinal column is a common feature of primary tumors of the breast, prostate, lung, and other organs. Surgical intervention can be performed via the traditional open surgery (OS) approach or the minimally invasive surgery (MIS) approach. This study aims to assess the available evidence of perioperative outcomes of MIS versus OS for patients with metastatic spinal disease.

We followed recommended PRISMA guidelines for systematic reviews. Six electronic databases were searched to identify all potentially relevant studies published from inception to October 2017. Data were extracted and analyzed using meta-analysis of proportions.

Six studies satisfied the criteria for inclusion into this study. There were 292 patients with metastatic spinal disease described in the cohort, treated with either MIS (n = 155, 53%) or OS (n = 137, 47%). Compared with OS, MIS …