作者
Marie C Bradley, Yoganand Chillarige, Hana Lee, Xiyuan Wu, Shruti Parulekar, Stella Muthuri, Michael Wernecke, Thomas E MaCurdy, Jeffrey A Kelman, David J Graham
发表日期
2021/5/1
期刊
JAMA Internal Medicine
卷号
181
期号
5
页码范围
598-607
出版商
American Medical Association
简介
Importance
Previous studies have found that the risk of severe hypoglycemia does not differ between long-acting insulin analogs and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes. However, these studies did not focus on patients 65 years or older, who are at an increased risk for hypoglycemia, or did not include patients with concomitant prandial insulin use.
Objective
To examine the risk of emergency department (ED) visits or hospitalizations for hypoglycemia among older community-residing patients with type 2 diabetes who initiated long-acting insulin or NPH insulin in real-world settings.
Design, Setting, and Participants
This retrospective, new-user cohort study assessed Medicare beneficiaries 65 years or older who initiated insulin glargine (n = 407 018), insulin detemir (n = 141 588), or NPH insulin (n = 26 402) from January 1, 2007, to July 31, 2019.
Exposures
Insulin glargine, insulin …
学术搜索中的文章
MC Bradley, Y Chillarige, H Lee, X Wu, S Parulekar… - JAMA Internal Medicine, 2021