作者
Veronica Sansing-Foster, Nicole Haug, Andrew Mosholder, Noelle M Cocoros, Marie Bradley, Yong Ma, Dinci Pennap, Elizabeth C Dee, Sengwee Toh, Ella Pestine, Andrew B Petrone, Ivone Kim, Jennifer G Lyons, Efe Eworuke
发表日期
2021/1/1
期刊
The Journal of Allergy and Clinical Immunology: In Practice
卷号
9
期号
1
页码范围
385-393. e12
出版商
Elsevier
简介
Background
There have been conflicting results from observational studies regarding the risk of psychiatric adverse events (PAEs) with montelukast use.
Objective
To determine whether there are associations of depressive disorders, self-harm, and suicide with use of montelukast compared with inhaled corticosteroid (ICS) use.
Methods
Using data from the Sentinel Distributed Database from January 1, 2000, to September 30, 2015, patients (n = 457,377) exposed to montelukast or ICS, aged 6 years and older with a diagnosis of asthma, were matched 1:1 on propensity scores. Hazard ratios (HRs) and 95% CIs were estimated for each study outcome overall and by age, sex, psychiatric history, and pre-/post-2008 labeling updates using Cox proportional hazards regression models.
Results
Exposure to montelukast was associated with a lower risk of treated outpatient depressive disorder (HR, 0.91; 95% CI, 0.89-0.93 …
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V Sansing-Foster, N Haug, A Mosholder, NM Cocoros… - The Journal of Allergy and Clinical Immunology: In …, 2021