作者
João Delgado, Lindsay Jones, Marie C Bradley, Louise M Allan, Clive Ballard, Linda Clare, Richard H Fortinsky, Carmel M Hughes, David Melzer
发表日期
2021/3
期刊
Age and Ageing
卷号
50
期号
2
页码范围
457-464
出版商
Oxford University Press
简介
Importance
treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown.
Objective
to estimate the rate of PIP and its effect on adverse health outcomes (AHO).
Design
retrospective cohort.
Setting
primary care electronic health records linked to hospital discharge data from England.
Subjects
11,175 individuals with dementia aged over 65 years in 2016 and 43,463 age- and sex-matched controls.
Methods
Screening Tool of Older Persons’ Prescriptions V2 defined PIP. Logistic regression tested associations with comorbidities at baseline, and survival analyses risk of incident AHO, adjusted for age, gender, deprivation and 14 comorbidities.
Results
the dementia group …
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J Delgado, L Jones, MC Bradley, LM Allan, C Ballard… - Age and Ageing, 2021