作者
Teenie Siu, Sandhya Sahye-Pudaruth, Fahmida Mannan, Raphael Blanc, Andreea Zurbau, Melanie Paquette, Darshna Patel, Laura Chiavaroli, Sonia Blanco Mejia, Tauseef Khan, Cyril Kendall, John L Sievenpiper, David Jenkins
发表日期
2023/11/7
来源
Circulation
卷号
148
期号
Suppl_1
页码范围
A13681-A13681
出版商
Lippincott Williams & Wilkins
简介
Background: Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite of red meat, has emerged as a potential biomarker for CVD and all-cause mortality. It is also found in preformed amounts in fish. However, the association between serum TMAO levels and CVD outcomes remain unclear.
Aim: To conduct a systematic review and dose-response meta-analysis evaluating the association between serum TMAO and CVD and all-cause mortality in prospective cohort studies.
Methods: A comprehensive literature search was conducted in MEDLINE, EMBASE, and Cochrane Library up to and including March 6, 2023. A manual search through references found in reviews and meta-analyses was also conducted. Studies reporting hazard ratios (HRs) or relative risks (RRs) with 95% confidence intervals (CIs) for the association between serum TMAO levels and CVD or all-cause mortality in adults ≥ 18 years …
学术搜索中的文章
T Siu, S Sahye-Pudaruth, F Mannan, R Blanc, A Zurbau… - Circulation, 2023