作者
Carlo Alberto Artusi, Roberta Balestrino, Gabriele Imbalzano, Sara Bortolani, Elisa Montanaro, Sara Tuttobene, Margherita Fabbri, Maurizio Zibetti, Leonardo Lopiano
发表日期
2020/7/1
期刊
Parkinsonism & Related Disorders
卷号
76
页码范围
98-103
出版商
Elsevier
简介
Introduction
Although levodopa/carbidopa intestinal infusion (LCIG) proved a sustained efficacy on Parkinson's disease (PD) motor fluctuations, there is a lack of studies on mortality of LCIG patients. In this study, we aimed at analyzing mortality and its predictors in a cohort of 105 PD patients treated with LCIG for over 10 years.
Methods
The death rate, death causes, mortality predictors, and serious adverse events (SAEs) were analyzed. A Cox regression model was used to estimate the influence of several demographic and clinical factors on mortality, and a binary logistic regression to evaluate the association between SAEs number and mortality. Kaplan-Meier and Log-rank test was used for a survival comparison between patients with an early drop-out (within 3 years since LCIG start) and patients continuing LCIG.
Results
Ninety-eight advanced PD patients treated with LCIG were included. During follow-up, 34.7 …
学术搜索中的文章
Beyond 10 years of levodopa intestinal infusion experience: Analysis of mortality and its predictors
CA Artusi, R Balestrino, G Imbalzano, S Bortolani… - Parkinsonism & Related Disorders, 2020