作者
Qiong Wang, Tengteng Tang, David Cooper, Felipe Eltit, Peter Fratzl, Pierre Guy, Rizhi Wang
发表日期
2020/11/1
期刊
Journal of Structural Biology
卷号
212
期号
2
页码范围
107606
出版商
Academic Press
简介
Bone becomes more fragile with ageing. Among many structural changes, a thin layer of highly mineralized and brittle tissue covers part of the external surface of the thin femoral neck cortex in older people and has been proposed to increase hip fragility. However, there have been very limited reports on this hypermineralized tissue in the femoral neck, especially on its ultrastructure. Such information is critical to understanding both the mineralization process and its contributions to hip fracture. Here, we use multiple advanced techniques to characterize the ultrastructure of the hypermineralized tissue in the neck across various length scales. Synchrotron radiation micro-CT found larger but less densely distributed cellular lacunae in hypermineralized tissue than in lamellar bone. When examined under FIB-SEM, the hypermineralized tissue was mainly composed of mineral globules with sizes varying from submicron …
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Q Wang, T Tang, D Cooper, F Eltit, P Fratzl, P Guy… - Journal of Structural Biology, 2020