作者
Lambertus A Kiemeney, Patrick Sulem, Soren Besenbacher, Sita H Vermeulen, Asgeir Sigurdsson, Gudmar Thorleifsson, Daniel F Gudbjartsson, Simon N Stacey, Julius Gudmundsson, Carlo Zanon, Jelena Kostic, Gisli Masson, Hjordis Bjarnason, Stefan T Palsson, Oskar B Skarphedinsson, Sigurjon A Gudjonsson, J Alfred Witjes, Anne J Grotenhuis, Gerald W Verhaegh, D Timothy Bishop, Sei Chung Sak, Ananya Choudhury, Faye Elliott, Jennifer H Barrett, Carolyn D Hurst, Petra J De Verdier, Charlotta Ryk, Peter Rudnai, Eugene Gurzau, Kvetoslava Koppova, Paolo Vineis, Silvia Polidoro, Simonetta Guarrera, Carlotta Sacerdote, Marcello Campagna, Donatella Placidi, Cecilia Arici, Maurice P Zeegers, Eliane Kellen, Berta Saez Gutierrez, José I Sanz-Velez, Manuel Sanchez-Zalabardo, Gabriel Valdivia, Maria D Garcia-Prats, Jan G Hengstler, Meinolf Blaszkewicz, Holger Dietrich, Roel A Ophoff, Leonard H Van Den Berg, Kristin Alexiusdottir, Kristleifur Kristjansson, Gudmundur Geirsson, Sigfus Nikulasson, Vigdis Petursdottir, Augustine Kong, Thorgeir Thorgeirsson, N Aydin Mungan, Annika Lindblom, Michael A Van Es, Stefano Porru, Frank Buntinx, Klaus Golka, José I Mayordomo, Rajiv Kumar, Giuseppe Matullo, Gunnar Steineck, Anne E Kiltie, Katja KH Aben, Eirikur Jonsson, Unnur Thorsteinsdottir, Margaret A Knowles, Thorunn Rafnar, Kari Stefansson
发表日期
2010/5
期刊
Nature genetics
卷号
42
期号
5
页码范围
415-419
出版商
Nature Publishing Group US
简介
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set and tested the top 20 markers from the combined analysis in several European case-control sample sets, with a total of 4,739 cases and 45,549 controls. The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 × 10−12). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC. Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low-grade stage Ta tumors. The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type …
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LA Kiemeney, P Sulem, S Besenbacher… - Nature genetics, 2010