作者
Thorunn Rafnar, Patrick Sulem, Simon N Stacey, Frank Geller, Julius Gudmundsson, Asgeir Sigurdsson, Margret Jakobsdottir, Hafdis Helgadottir, Steinunn Thorlacius, Katja KH Aben, Thorarinn Blöndal, Thorgeir E Thorgeirsson, Gudmar Thorleifsson, Kristleifur Kristjansson, Kristin Thorisdottir, Rafn Ragnarsson, Bardur Sigurgeirsson, Halla Skuladottir, Tomas Gudbjartsson, Helgi J Isaksson, Gudmundur V Einarsson, Kristrun R Benediktsdottir, Bjarni A Agnarsson, Karl Olafsson, Anna Salvarsdottir, Hjordis Bjarnason, Margret Asgeirsdottir, Kari T Kristinsson, Sigurborg Matthiasdottir, Steinunn G Sveinsdottir, Silvia Polidoro, Veronica Höiom, Rafael Botella-Estrada, Kari Hemminki, Peter Rudnai, D Timothy Bishop, Marcello Campagna, Eliane Kellen, Maurice P Zeegers, Petra De Verdier, Ana Ferrer, Dolores Isla, Maria Jesus Vidal, Raquel Andres, Berta Saez, Pablo Juberias, Javier Banzo, Sebastian Navarrete, Alejandro Tres, Donghui Kan, Annika Lindblom, Eugene Gurzau, Kvetoslava Koppova, Femmie De Vegt, Jack A Schalken, Henricus FM Van Der Heijden, Hans J Smit, René A Termeer, Egbert Oosterwijk, Onno Van Hooij, Eduardo Nagore, Stefano Porru, Gunnar Steineck, Johan Hansson, Frank Buntinx, William J Catalona, Giuseppe Matullo, Paolo Vineis, Anne E Kiltie, José I Mayordomo, Rajiv Kumar, Lambertus A Kiemeney, Michael L Frigge, Thorvaldur Jonsson, Hafsteinn Saemundsson, Rosa B Barkardottir, Eirikur Jonsson, Steinn Jonsson, Jon H Olafsson, Jeffrey R Gulcher, Gisli Masson, Daniel F Gudbjartsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson
发表日期
2009/2
期刊
Nature genetics
卷号
41
期号
2
页码范围
221-227
出版商
Nature Publishing Group US
简介
The common sequence variants that have recently been associated with cancer risk are particular to a single cancer type or at most two. Following up on our genome-wide scan of basal cell carcinoma, we found that rs401681[C] on chromosome 5p15.33 satisfied our threshold for genome-wide significance (OR = 1.25, P = 3.7 × 10−12). We tested rs401681 for association with 16 additional cancer types in over 30,000 cancer cases and 45,000 controls and found association with lung cancer (OR = 1.15, P = 7.2 × 10−8) and urinary bladder, prostate and cervix cancer (ORs = 1.07−1.31, all P < 4 × 10−4). However, rs401681[C] seems to confer protection against cutaneous melanoma (OR = 0.88, P = 8.0 × 10−4). Notably, most of these cancer types have a strong environmental component to their risk. Investigation of the region led us to rs2736098[A], which showed stronger association with some cancer types …
引用总数
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T Rafnar, P Sulem, SN Stacey, F Geller… - Nature genetics, 2009