作者
Niels Høiby, Oana Ciofu, Helle Krogh Johansen, Zhi‐jun Song, Claus Moser, Peter Østrup Jensen, Søren Molin, Michael Givskov, Tim Tolker‐Nielsen, Thomas Bjarnsholt
发表日期
2011/4
来源
International journal of oral science
卷号
3
期号
2
页码范围
55-65
出版商
Nature Publishing Group
简介
Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self‐produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times …
引用总数
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学术搜索中的文章
N Høiby, O Ciofu, HK Johansen, Z Song, C Moser… - International journal of oral science, 2011