作者
Vincent Feng-Sheng Shih, Rachel Tsui, Andrew Caldwell, Alexander Hoffmann
发表日期
2011/1
来源
Cell research
卷号
21
期号
1
页码范围
86-102
出版商
Nature Publishing Group
简介
Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical pathway that mediates inflammatory responses, and the non-canonical pathway that is involved in immune cell differentiation and maturation and secondary lymphoid organogenesis. The former is dependent on the IκB kinase adaptor molecule NEMO, the latter is independent of it. Here, we review the molecular mechanisms of regulation in each signaling axis and attempt to relate the apparent regulatory logic to the physiological function. Further, we review the recent evidence for extensive cross-regulation between these two signaling axes and summarize them in a wiring diagram. These observations suggest that NEMO-dependent and-independent signaling should be viewed within the context of a single NFκB signaling system, which mediates signaling from both inflammatory and organogenic stimuli in an integrated …
学术搜索中的文章
VFS Shih, R Tsui, A Caldwell, A Hoffmann - Cell research, 2011