作者
Muneo Numasaki, Mika Watanabe, Takashi Suzuki, Hidenori Takahashi, Akira Nakamura, Florencia McAllister, Takanori Hishinuma, Junichi Goto, Michael T Lotze, Jay K Kolls, Hidetada Sasaki
发表日期
2005/11/1
期刊
The Journal of Immunology
卷号
175
期号
9
页码范围
6177-6189
出版商
American Association of Immunologists
简介
In this study, we examined the biological action of IL-17 on human non-small cell lung cancer (NSCLC). Although IL-17 had no direct effect on the in vitro growth rate of NSCLC, IL-17 selectively augmented the secretion of an array of angiogenic CXC chemokines, including CXCL1, CXCL5, CXCL6, and CXCL8 but not angiostatic chemokines, by three different NSCLC lines. Endothelial cell chemotactic activity (as a measure of net angiogenic potential) was increased in response to conditioned medium from NSCLC stimulated with IL-17 compared with those from unstimulated NSCLC. Enhanced chemotactic activity was suppressed by neutralizing mAb (s) to CXCL1, CXCL5, and CXCL8 or to CXCR-2 but not to vascular endothelial growth factor-A. Transfection with IL-17 into NSCLC had no effect on the in vitro growth, whereas IL-17 transfectants grew more rapidly compared with controls when transplanted in SCID …
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M Numasaki, M Watanabe, T Suzuki, H Takahashi… - The Journal of Immunology, 2005