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Interleukin (IL)-17-producing T helper cells (T_H17) are a recently identified CD4⁺ T cell subset distinct from T helper type 1 (T_H1) and T helper type 2 (T_H2) cells. T_H17 cells can drive antigen-specific autoimmune diseases and are considered the main population of pathogenic T cells driving experimental autoimmune encephalomyelitis (EAE), the mouse model for multiple sclerosis. The factors that are needed for the generation of T_H17 cells have been well characterized^,,,. However, where and how the immune system controls T_H17 cells in vivo remains unclear. Here, by using a model of tolerance induced by CD3-specific antibody, a model of sepsis and influenza A viral infection (H1N1), we show that pro-inflammatory T_H17 cells can be redirected to and controlled in the small intestine. T_H17-specific IL-17A secretion induced expression of the chemokine CCL20 in the small intestine, facilitating the migration of …