作者
Kyle I Happel, Mingquan Zheng, Erana Young, Lee J Quinton, Euan Lockhart, Alistair J Ramsay, Judd E Shellito, Jill R Schurr, Gregory J Bagby, Steve Nelson, Jay K Kolls
发表日期
2003/5/1
期刊
The Journal of Immunology
卷号
170
期号
9
页码范围
4432-4436
出版商
American Association of Immunologists
简介
Local production of IL-17 is a significant factor in effective host defense against Gram-negative bacteria. However, the proximal events mediating IL-17 elaboration by T cells remain unclear. In this study, we show in vivo that intact Toll-like receptor 4 signaling in the lung is required for induction of both the p19 transcript of IL-23 and IL-17 protein elaboration in response to Klebsiella pneumoniae. Although IL-17 is widely considered a CD4+ T cell product, we also demonstrate significant in vitro IL-17 production by CD8+ T cells after culture in medium from dendritic cells exposed to these bacteria. The dominant portion of this IL-17-inducing activity for both CD4+ and CD8+ T cells is IL-23. These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8+ T cell IL-17 production.
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KI Happel, M Zheng, E Young, LJ Quinton, E Lockhart… - The Journal of Immunology, 2003