作者
Liwei Ren, Yuan Sun, Hong Lu, Dien Ye, Lijuan Han, Na Wang, Alan Daugherty, Furong Li, Miaomiao Wang, Fengting Su, Wenjun Tao, Jie Sun, Noam Zelcer, Adam E Mullick, AH Jan Danser, Yizhou Jiang, Yongcheng He, Xiongzhong Ruan, Xifeng Lu
发表日期
2018/3/2
期刊
Circulation research
卷号
122
期号
5
页码范围
730-741
出版商
Lippincott Williams & Wilkins
简介
Rationale:
An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates LDL metabolism in vitro via the LDLR (LDL receptor) and SORT1 (sortilin-1), independently of the renin–angiotensin system.
Objectives:
To investigate the physiological role of (P)RR in lipid metabolism in vivo.
Methods and Results:
We used N-acetylgalactosamine modified antisense oligonucleotides to specifically inhibit hepatic (P)RR expression in C57BL/6 mice and studied the consequences this has on lipid metabolism. In line with our earlier report, hepatic (P)RR silencing increased plasma LDL-C (LDL cholesterol). Unexpectedly, this also resulted in markedly reduced plasma triglycerides in a SORT1-independent manner in C57BL/6 mice fed a normal- or high-fat diet. In LDLR-deficient mice, hepatic (P)RR inhibition …
学术搜索中的文章
L Ren, Y Sun, H Lu, D Ye, L Han, N Wang, A Daugherty… - Circulation research, 2018
