作者
David W Zhang, Juan B Rodríguez-Molina, Joshua R Tietjen, Corey M Nemec, Aseem Z Ansari
发表日期
2012
来源
Genetics research international
卷号
2012
期号
1
页码范围
347214
出版商
Hindawi Publishing Corporation
简介
The C‐terminal domain (CTD) of RNA polymerase II (Pol II) consists of conserved heptapeptide repeats that function as a binding platform for different protein complexes involved in transcription, RNA processing, export, and chromatin remodeling. The CTD repeats are subject to sequential waves of posttranslational modifications during specific stages of the transcription cycle. These patterned modifications have led to the postulation of the “CTD code” hypothesis, where stage‐specific patterns define a spatiotemporal code that is recognized by the appropriate interacting partners. Here, we highlight the role of CTD modifications in directing transcription initiation, elongation, and termination. We examine the major readers, writers, and erasers of the CTD code and examine the relevance of describing patterns of posttranslational modifications as a “code.” Finally, we discuss major questions regarding the function of …
学术搜索中的文章
DW Zhang, JB Rodríguez-Molina, JR Tietjen… - Genetics research international, 2012