作者
Shinjini Chakraborty, Veronika Eva Winkelmann, Sonja Braumüller, Annette Palmer, Anke Schultze, Bettina Klohs, Anita Ignatius, Axel Vater, Michael Fauler, Manfred Frick, Markus Huber-Lang
发表日期
2021/1/25
期刊
Scientific Reports
卷号
11
期号
1
页码范围
2158
出版商
Nature Publishing Group UK
简介
Singular blockade of C5a in experimental models of sepsis is known to confer protection by rescuing lethality and decreasing pro-inflammatory responses. However, the role of inhibiting C5a has not been evaluated in the context of sterile systemic inflammatory responses, like polytrauma and hemorrhagic shock (PT + HS). In our presented study, a novel and highly specific C5a L-aptamer, NoxD21, was used to block C5a activity in an experimental murine model of PT + HS. The aim of the study was to assess early modulation of inflammatory responses and lung damage 4 h after PT + HS induction. NoxD21-treated PT + HS mice displayed greater polymorphonuclear cell recruitment in the lung, increased pro-inflammatory cytokine levels in the bronchoalveolar lavage fluids (BALF) and reduced myeloperoxidase levels within the lung tissue. An in vitro model of the alveolar-capillary barrier was established to …
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S Chakraborty, VE Winkelmann, S Braumüller… - Scientific reports, 2021