作者
Alexander G Weil, Evan C Lewis, George M Ibrahim, Olivia Kola, ChiHong Tseng, Xinkai Zhou, KaoMin Lin, LiXin Cai, QingZhu Liu, JiuLuan Lin, WenJing Zhou, Gary W Mathern, Matthew D Smyth, Brent R O'Neill, Roy Dudley, John Ragheb, Sanjiv Bhatia, Daniel Delev, Georgia Ramantani, Josef Zentner, Jeffrey Ojemann, Anthony C Wang, Christian Dorfer, Martha Feucht, Thomas Czech, Robert J Bollo, Galymzhan Issabekov, Hongwei Zhu, Mary Connelly, Paul Steinbok, JianGuo Zhang, Kai Zhang, Eveline Teresa Hidalgo, Howard L Weiner, Lily WongKisiel, Samuel LapalmeRemis, Manjari Tripathi, Poodipedi Sarat Chandra, Walter Hader, FengPeng Wang, Yi Yao, Pierre Olivier Champagne, Qiang Guo, ShaoChun Li, Marcelo Budke, Maria Angeles PérezJiménez, Christian Raftapoulos, Patrice Finet, Pauline Michel, Karl Schaller, Martin N Stienen, Valentina Baro, Christian Cantillano Malone, Juan Pociecha, Noelia Chamorro, Valeria L Muro, Marec von Lehe, Silvia Vieker, Chima Oluigbo, William D Gaillard, Mashael Al Khateeb, Faisal Al Otaibi, Niklaus Krayenbühl, Jeffrey Bolton, Phillip L Pearl, Aria Fallah
发表日期
2021/5
期刊
Epilepsia
卷号
62
期号
5
页码范围
1064-1073
简介
Objective
To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drugresistant epilepsy.
Methods
We analyzed 1267 hemispheric surgeries performed in pediatric participants across 32 centers and 12 countries to identify predictors of seizure freedom at 3 months after surgery. A multivariate logistic regression model was developed based on 70% of the dataset (training set) and validated on 30% of the dataset (validation set). Missing data were handled using multiple imputation techniques.
Results
Overall, 817 of 1237 (66%) hemispheric surgeries led to seizure freedom (median followup = 24 months), and 1050 of 1237 (85%) were seizurefree at 12 months after surgery. A simple regression model containing age at seizure onset, presence of generalized seizure semiology, presence of contralateral 18fluoro2deoxyglucose …
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AG Weil, EC Lewis, GM Ibrahim, O Kola, CH Tseng… - Epilepsia, 2021