作者
Eduard HJ Voormolen, Pierre Olivier Champagne, Elena Roca, Lorenzo Giammattei, Thibault Passeri, Paolo di Russo, Miguel Marigil Sanchez, Anne Laure Bernat, Isabelle Yoldjian, Sylvie Fontanel, Alain Weill, Emmanuel Mandonnet, Sébastien Froelich
发表日期
2021/8/1
期刊
Neurosurgery
卷号
89
期号
2
页码范围
308-314
出版商
LWW
简介
OBJECTIVE
To investigate the relationship between growth kinetics of intracranial meningiomas and usage of the progestin cyproterone acetate (PCA).
METHODS
This study prospectively followed 108 women with 262 intracranial meningiomas and documented PCA use. A per-meningioma analysis was conducted. Changes in meningioma volumes over time, and meningioma growth velocities, were measured on magnetic resonance imaging (MRI) after stopping PCA treatment.
RESULTS
Mean follow-up time was 30 (standard deviation [SD] 29) mo. Ten (4%) meningiomas were treated surgically at presentation. The other 252 meningiomas were followed after stopping PCA treatment. Overall, followed meningiomas decreased their volumes by 33% on average (SD 28%). A total of 188 (72%) meningiomas decreased, 51 (20%) meningiomas remained stable, and 13 (4%) increased in volume of which 3 (1%) were …
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EHJ Voormolen, PO Champagne, E Roca… - Neurosurgery, 2021