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Recent findings have demonstrated that environmental factors, including chemicals, pollutants, and nutrition, have an effect on human health. Epigenetic gene regulation can be influenced by a variety of environmental factors, and their aberrations including DNA methylation in imprinted and developmental genes, histone tail modifications, and short noncoding RNAs have been implicated in various human diseases. The human epigenome is susceptible to environmentally induced changes and pollutants. Many studies have showed that epigenetic modifications have a role in gametogenesis. The effects of environmental factors such as occupational and environmental exposures and exposures resulting from lifestyle choices or medical treatments can lead to epigenetic alterations in the onset of puberty and gametogenesis. Both female and male gamete cells undergo developmental epigenetic alterations …