作者
Edward T Qian, Jonathan D Casey, Adam Wright, Li Wang, Matthew S Shotwell, Justin K Siemann, Mary Lynn Dear, Joanna L Stollings, Brad D Lloyd, Tanya K Marvi, Kevin P Seitz, George E Nelson, Patty W Wright, Edward D Siew, Bradley M Dennis, Jesse O Wrenn, Jonathan W Andereck, Jin H Han, Wesley H Self, Matthew W Semler, Todd W Rice, Gordon R Bernard, Robert S Dittus, Shon Dwyer, Peter J Embi, Robert E Freundlich, Cheryl L Gatto, Frank E Harrell, Paul A Harris, Tina Hartert, Jim Hayman, Catherine H Ivory, Ruth Kleinpell, Sunil Kripalani, Christopher J Lindsell, Lee A Liska, Patrick Luther, Jay Morrison, Thomas Nantais, Jill M Pulley, Kris Rehm, Todd W Rice, Russel L Rotheman, Patti Runyan, Wesley H Self, Matthew W Semler, Robin Steaban, Cosby A Stone, Philip D Walker, Consuelo H Wilkens, Autumn D Zukerman, Chad Fitzgerald, Jonathan D Casey, Kevin P Seitz, Jillian Rhoads, Kelsey Womack, Brant Imhoff, Matthew S Shotwell
发表日期
2023/10/24
期刊
Jama
卷号
330
期号
16
页码范围
1557-1567
出版商
American Medical Association
简介
Importance
Cefepime and piperacillin-tazobactam are commonly administered to hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has been hypothesized to cause acute kidney injury and cefepime has been hypothesized to cause neurological dysfunction, their comparative safety has not been evaluated in a randomized clinical trial.
Objective
To determine whether the choice between cefepime and piperacillin-tazobactam affects the risks of acute kidney injury or neurological dysfunction.
Design, Setting, and Participants
The Antibiotic Choice on Renal Outcomes (ACORN) randomized clinical trial compared cefepime vs piperacillin-tazobactam in adults for whom a clinician initiated an order for antipseudomonal antibiotics within 12 hours of presentation to the hospital in the emergency department or medical intensive care unit at an academic medical center in the US between …
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ET Qian, JD Casey, A Wright, L Wang, MS Shotwell… - Jama, 2023