作者
Trina Basu, Jamie Maguire, Jay A Salpekar
发表日期
2021/2/16
来源
Neuroscience letters
卷号
746
页码范围
135618
出版商
Elsevier
简介
Stress is a common seizure trigger in persons with epilepsy. The body’s physiological response to stress is mediated by the hypothalamic-pituitary-adrenal (HPA) axis and involves a hormonal cascade that includes corticotropin releasing hormone (CRH), adrenocorticotropin releasing hormone (ACTH) and the release of cortisol (in humans and primates) or corticosterone (in rodents). The prolonged exposure to stress hormones may not only exacerbate pre-existing medical conditions including epilepsy, but may also increase the predisposition to psychiatric comorbidities. Hyperactivity of the HPA axis negatively impacts the structure and function of the temporal lobe of the brain, a region that is heavily involved in epilepsy and mood disorders like anxiety and depression. Seizures themselves damage temporal lobe structures, further disinhibiting the HPA axis, setting off a vicious cycle of neuronal damage and …
学术搜索中的文章
T Basu, J Maguire, JA Salpekar - Neuroscience letters, 2021