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Cinnamaldehyde, a bioactive component of cinnamon, is increasingly gaining interest for its preventive and therapeutic effects against metabolic complications like type‐2 diabetes. This study is an attempt to understand the effect of cinnamaldehyde in high‐fat diet (HFD)‐associated increase in fasting‐induced hyperphagia and related hormone levels, adipose tissue lipolysis and inflammation, and selected cecal microbial count in mice. Cinnamaldehyde, at 40 µm dose, prevented lipid accumulation and altered gene expression toward lipolytic phenotype in 3T3‐L1 preadipocyte cell lines. In vivo, cinnamaldehyde coadministration prevented HFD‐induced body weight gain, decreased fasting‐induced hyperphagia, as well as circulating leptin and leptin/ghrelin ratio. In addition to that, cinnamaldehyde altered serum biochemical parameters related to lipolysis, that is, glycerol and free fatty acid levels. At …