作者
Francis X Guyette, Joshua B Brown, Mazen S Zenati, Barbara J Early-Young, Peter W Adams, Brian J Eastridge, Raminder Nirula, Gary A Vercruysse, Terence O’Keeffe, Bellal Joseph, Louis H Alarcon, Clifton W Callaway, Brian S Zuckerbraun, Matthew D Neal, Raquel M Forsythe, Matthew R Rosengart, Timothy R Billiar, Donald M Yealy, Andrew B Peitzman, Jason L Sperry, STAAMP Study Group
发表日期
2021/1/1
期刊
JAMA surgery
卷号
156
期号
1
页码范围
11-20
出版商
American Medical Association
简介
Importance
In-hospital administration of tranexamic acid after injury improves outcomes in patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic use of tranexamic acid in the prehospital phase of care are lacking for these patients.
Objective
To assess the effectiveness and safety of tranexamic acid administered before hospitalization compared with placebo in injured patients at risk for hemorrhage.
Design, Setting, and Participants
This pragmatic, phase 3, multicenter, double-blind, placebo-controlled, superiority randomized clinical trial included injured patients with prehospital hypotension (systolic blood pressure ≤90 mm Hg) or tachycardia (heart rate ≥110/min) before arrival at 1 of 4 US level 1 trauma centers, within an estimated 2 hours of injury, from May 1, 2015, through October 31, 2019.
Interventions
Patients received 1 g of tranexamic acid before hospitalization (447 …
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FX Guyette, JB Brown, MS Zenati, BJ Early-Young… - JAMA surgery, 2021
