作者
Błażej Rubiś, Hanna Hołysz, Wojciech Barczak, Robert Gryczka, Mariusz Łaciński, Paweł Jagielski, Anna Czernikiewicz, Anna Półrolniczak, Aneta Wojewoda, Katarzyna Perz, Paweł Białek, Karolina Morze, Zuzanna Kanduła, Natalia Lisiak, Przemysław M Mrozikiewicz, Sylwia Grodecka-Gazdecka, Maria Rybczyńska
发表日期
2012/11/1
期刊
Pharmacological Reports
卷号
64
期号
6
页码范围
1560-1566
出版商
No longer published by Elsevier
简介
Background
The accumulation of mutagenic substances in the human body may result in DNA metabolism disruption followed by carcinogenesis. As a consequence of mutations in the genes coding for transmembrane protein pumps, the intracellular concentration of xenobiotics may significantly increase. This, in turn, may provoke altered risk for cancer development. The gene known to be the most relevant in the transport of numerous compounds is ABCB1 (also known as MDR1). Numerous mutations and polymorphisms that affect the encoded protein's (PgP) function were identified in this gene.
The aim of the study was to define the frequency of 2677G > A,T and 3435C > T polymorphisms in a population of Polish breast cancer patients and to estimate their contribution to cancer development.
Methods
The polymorphism frequency analysis (209 patients vs. 202 control subjects) was performed either by allele …
学术搜索中的文章
B Rubiś, H Hołysz, W Barczak, R Gryczka, M Łaciński… - Pharmacological Reports, 2012