作者
Adelfo Escalante, Ania Salinas Cervantes, Guillermo Gosset, Francisco Bolívar
发表日期
2012/6
来源
Applied microbiology and biotechnology
卷号
94
页码范围
1483-1494
出版商
Springer-Verlag
简介
In Escherichia coli, the phosphoenolpyruvate–carbohydrate phosphotransferase system (PTS) is responsible for the transport and phosphorylation of sugars, such as glucose. PTS activity has a crucial role in the global signaling system that controls the preferential consumption of glucose over other carbon sources. When the cell is exposed to carbohydrate mixtures, the PTS prevents the expression of catabolic genes and activity of non-PTS sugars transport systems by carbon catabolite repression (CCR). This process defines some metabolic and physiological constraints that must be considered during the development of production strains. In this review, we summarize the importance of the PTS in controlling and influencing both PTS and non-PTS sugar transport processes as well as the mechanisms of transcriptional control involved in the expression of catabolic genes of non-PTS sugars in E. coli. We …
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A Escalante, A Salinas Cervantes, G Gosset, F Bolívar - Applied microbiology and biotechnology, 2012