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To assess cataract progression after intravitreal triamcinolone injection.

Retrospective, interventional, case-control study.

Forty-two phakic eyes of 37 patients were injected one, two, or three times with intravitreal triamcinolone for various indications. Noninjected phakic fellow eyes served as the control. The mean follow-up time for single injection was 12 months, for multiple injections was 14 months, and for control group was 13 months. Lens status, best-corrected visual acuity, and refractive errors were recorded at baseline and at each follow-up examination.

At the last follow-up, changes in posterior subcapsular cataract and refractive error from baseline were significantly different between single triamcinolone-injected eyes and the control group [0.7 ± 0.2 (mean ± SEM [arbitrary unit] vs 0.2 ± 0.1, P = .02; and −0.5 ± 0.1 diopter vs −0.2 ± 0.1 diopter, P = .01, respectively …