作者
Jerrold H Levy, Lawrence T Goodnough, Philip E Greilich, Grant VS Parr, Robert W Stewart, Irwin Gratz, Joyce Wahr, John Williams, Mark E Comunale, Dennis Doblar, George Silvay, Marc Cohen, Jonathan S Jahr, Gus J Vlahakes
发表日期
2002/7/1
期刊
The Journal of thoracic and cardiovascular surgery
卷号
124
期号
1
页码范围
35-42
出版商
Mosby
简介
Background
Blood loss leading to reduced oxygen-carrying capacity is usually treated with red blood cell transfusions. This study examined the hypothesis that a hemoglobin-based oxygen-carrying solution can serve as an initial alternative to red blood cell transfusion.
Methods
In a randomized, double-blind efficacy trial of HBOC-201, a total of 98 patients undergoing cardiac surgery and requiring transfusion were randomly assigned to receive either red blood cell units or HBOC-201 (Hemopure; Biopure Corporation, Cambridge, Mass) for the first three postoperative transfusions. Patients were monitored before and after transfusion, at discharge, and at 3 to 4 weeks after the operation for subsequent red blood cell use, hemodynamics, and clinical laboratory parameters.
Results
The use of HBOC-201 eliminated the need for red blood cell transfusions in 34% of cases (95% confidence interval 21%-49%). Patients in …
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JH Levy, LT Goodnough, PE Greilich, GVS Parr… - The Journal of thoracic and cardiovascular surgery, 2002