作者
Janna K Duong, Shaun S Kumar, Carl M Kirkpatrick, Louise C Greenup, Manit Arora, Toong C Lee, Peter Timmins, Garry G Graham, Timothy J Furlong, Jerry R Greenfield, Kenneth M Williams, Richard O Day
发表日期
2013/5
期刊
Clinical pharmacokinetics
卷号
52
页码范围
373-384
出版商
Springer International Publishing AG
简介
Background and Objective
Metformin is contraindicated in patients with renal impairment; however, there is poor adherence to current dosing guidelines. In addition, the pharmacokinetics of metformin in patients with significant renal impairment are not well described. The aims of this study were to investigate factors influencing the pharmacokinetic variability, including variant transporters, between healthy subjects and patients with type 2 diabetes mellitus (T2DM) and to simulate doses of metformin at varying stages of renal function.
Methods
Plasma concentrations of metformin were pooled from three studies: patients with T2DM (study A; n = 120), healthy Caucasian subjects (study B; n = 16) and healthy Malaysian subjects (study C; n = 169). A population pharmacokinetic model of metformin was developed using NONMEM® version VI for both the …
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JK Duong, SS Kumar, CM Kirkpatrick, LC Greenup… - Clinical pharmacokinetics, 2013
