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We have designed two pulse sequences that give rise to COSY-type spectra with in-phase multiplet structure. In these spectra, the cross peaks are absorptive and in-phase along both dimensions. Such 2D spectra are useful for quantitative measurements, such as measurement of the extent of H/D exchange in proteins and measurement of the concentrations of individual components in a series of mixtures. These spectra can also be used to emphasize cross peaks between weakly coupled protons.