作者
Markus Pfirrmann, Richard E Clark, Witold Prejzner, Michael Lauseker, Michele Baccarani, Susanne Saussele, François Guilhot, Sonja Heibl, Rüdiger Hehlmann, Edgar Faber, Anna Turkina, Gert Ossenkoppele, Martin Höglund, Andrey Zaritskey, Laimonas Griskevicius, Ulla Olsson-Strömberg, Hele Everaus, Perttu Koskenvesa, Boris Labar, Tomasz Sacha, Daniela Zackova, Francisco Cervantes, Adriana Colita, Irena Zupan, Andrija Bogdanovic, Fausto Castagnetti, Joëlle Guilhot, Joerg Hasford, Andreas Hochhaus, Verena S Hoffmann
发表日期
2020/8
期刊
Leukemia
卷号
34
期号
8
页码范围
2138-2149
出版商
Nature Publishing Group UK
简介
Prognostic scores support clinicians in selecting risk-adjusted treatments and in comparatively assessing different results. For patients with chronic-phase chronic myeloid leukemia (CML), four baseline prognostic scores are commonly used. Our aim was to compare the prognostic performance of the scores and to arrive at an evidence-based score recommendation. In 2949 patients not involved in any score development, higher hazard ratios and concordance indices in any comparison demonstrated the best discrimination of long-term survival with the ELTS score. In a second step, of 5154 patients analyzed to investigate risk group classification differences, 23% (n = 1197) were allocated to high-risk by the Sokal score. Of the 1197 Sokal high-risk patients, 56% were non-high-risk according to the ELTS score and had a significantly more favorable long-term survival prognosis than the 526 high-risk patients …
学术搜索中的文章
M Pfirrmann, RE Clark, W Prejzner, M Lauseker… - Leukemia, 2020