作者
Gordana Tomac, Ines Bojanić, Sanja Mazić, Ivana Vidović, Mirela Raos, Branka Golubić Ćepulić, Ranka Serventi Seiwerth, Jadranka Kelečić, Boris Labar
发表日期
2018/7
期刊
Blood Transfusion
卷号
16
期号
4
页码范围
397
出版商
SIMTI Servizi
简介
Background
Acute and delayed haemolysis, alloimmunisation and pure red cell aplasia (PRCA) are potential complications after ABO incompatible haematopoietic stem cell transplantation (HSCT). The aims of this study were to investigate acute and delayed red blood cell (RBC) antibody-associated complications, including haemolysis, PRCA and alloimmunisation in major and bidirectional ABO incompatible HSCT.
Materials and methods
We retrospectively examined the transplant courses of 36 recipients of bone marrow or peripheral blood stem cells from ABO incompatible donors and evaluated the current practice of performing plasmapheresis in patients with higher isoagglutinin titres. We investigated the role of ABO incompatibility in haematopoietic recovery, transfusion requirements, alloimmunisation and PRCA.
Results
Laboratory signs of acute haemolysis were noted in five (14%) patients, one (3%) of …
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G Tomac, I Bojanić, S Mazić, I Vidović, M Raos… - Blood Transfusion, 2018