作者
Nienke R Biermasz, Alberto M Pereira, Jan WA Smit, Johannes A Romijn, Ferdinand Roelfsema
发表日期
2005/5/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
90
期号
5
页码范围
2731-2739
出版商
Oxford University Press
简介
Active acromegaly is associated with significant comorbidity and reduced quality of life. However, the prevalence of comorbidity after long-term remission is not established. Therefore, we assessed the presence of comorbidity in 118 patients in long-term remission after surgery, radiotherapy, and/or somatostatin analog treatment according to strict biochemical criteria of serum GH and IGF-I concentrations and evaluated the impact of comorbidity on quality of life. The mean duration of remission was 12.0 ± 7.4 yr, and mean actual IGF-I sd scores were 0.6 ± 1.7.
Self-reported joint problems occurred in 77% of patients, hypertension in 37%, a history of myocardial infarction in 9%, and diabetes mellitus in 11%. The presence of joint problems was not related to GH and IGF-I levels, active disease duration, or age. Joint complaints had significant negative impact on quality of life. Patients with a history of myocardial …
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NR Biermasz, AM Pereira, JWA Smit, JA Romijn… - The Journal of Clinical Endocrinology & Metabolism, 2005