作者
Takeo Hara, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Kotaro Yamashita, Yuya Nogi, Takuro Saito, Tsuyoshi Takahashi, Yukinori Kurokawa, Mitsuaki Tatsumi, Kiyokazu Nakajima, Eiichi Morii, Hidetoshi Eguchi, Yuichiro Doki
发表日期
2020/10
期刊
Annals of Surgical Oncology
卷号
27
页码范围
3762-3769
出版商
Springer International Publishing
简介
Background
Peri- or intra-tumor lymphangiogenesis is induced in several types of cancer. However, the significance of peritumoral lymphatic vessels (LVs) in esophageal cancer (EC) remains to be clarified.
Methods
This study included 162 eligible EC patients with or without neoadjuvant chemotherapy (NAC). The numbers of non-tumoral and peritumoral LVs were counted in resected specimens based on podoplanin immunostaining. The association between peritumoral LV number and clinicopathologic parameters, including tumor heterogeneity as measured by positron emission tomography, NAC response, and patient survival were analyzed.
Results
In non-NAC patients, the number of peritumoral LVs was highest in the lamina propria mucosa (LPM), followed by non-tumoral LVs in the LPM, peritumoral LVs in the submucosa (SM), and non-tumoral LVs in the SM. The patients with a low number of …
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T Hara, T Makino, M Yamasaki, K Tanaka, K Yamashita… - Annals of Surgical Oncology, 2020