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The present study used behavioral analyses to investigate the involvement of the NO/cGMP/K ATP pathway, serotoninergic, and opioid systems in the antinociceptive action of [(±)-(2, 4, 6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl] methanol (CTHP) in mice. Oral administration of CTHP (1, 5, 10, and 30 mg/kg) exerted effects at higher doses in chemical models of nociception (the acetic acid writhing and formalin tests) as well as a thermal model (the tail-flick test). It was also found that pretreatment with l-N G-nitroarginine methyl ester (nonselective nitric oxide synthase inhibitor), 1H-[1, 2, 4] oxadiazolo [4, 3-a] quinoxalin-1-one (selective inhibitor of nitric oxide-sensitive guanosyl cyclase), glibenclamide (selective ATP-sensitive K+ channel blocker), naloxone (nonselective opioid receptor blocker), and nor-binaltorphimine (selective κ-opioid receptor blocker), but not methylnaltrexone (peripheral μ …