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The adsorption of plasminogen, the principal protein of the fibrinolytic pathway in blood, to a number of solid surfaces has been investigated. This study forms part of a larger project, the objective of which is to develop a fibrinolytic surface for blood-contacting applications. Our approach is to create a material that will selectively adsorb plasminogen from blood by incorporating lysine residues (known to bind plasminogen) into the surface. Lysine-containing polyurethanes were used for this purpose. In the present work the adsorption of plasminogen to these surfaces as well as to glass, “conventional” polyurethanes, and precursor sulfonated polyurethanes was investigated. Adsorption from isotonic Tris buffer, pH 7.4, was measured under static conditions at room temperature using radioiodinated plasminogen. Most of the surfaces except glass reached isotherm plateaux at about 0.1 mg/ml solution concentration. The …