作者
Chao Zeng, Jie Wei, Monica SM Persson, Aliya Sarmanova, Michael Doherty, Dongxing Xie, YiLun Wang, Xiaoxiao Li, Jiatian Li, Huizhong Long, Guanghua Lei, Weiya Zhang
发表日期
2018/5/1
来源
British journal of sports medicine
卷号
52
期号
10
页码范围
642-650
出版商
BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
简介
Objectives
To compare the efficacy and safety of topical non-steroidal anti-inflammatory drugs (NSAIDs), including salicylate, for the treatment of osteoarthritis (OA).
Methods
PubMed, Embase, Cochrane Library and Web of Science were searched from 1966 to January 2017. Randomised controlled trials (RCTs) comparing topical NSAIDs with placebo or each other in patients with OA and observational studies comparing topical NSAIDs with no treatment or each other irrespective of disease were included. Two investigators identified studies and independently extracted data. Bayesian network and conventional meta-analyses were conducted. The primary outcomes were pain relief for RCTs and risk of adverse effects (AEs) for observational studies.
Results
43 studies, comprising 36 RCTs (7 900 patients with OA) and seven observational studies (218 074 participants), were included. Overall, topical NSAIDs were …
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C Zeng, J Wei, MSM Persson, A Sarmanova, M Doherty… - British journal of sports medicine, 2018