作者
David L Steward, Sally E Carty, Rebecca S Sippel, Samantha Peiling Yang, Julie A Sosa, Jennifer A Sipos, James J Figge, Susan Mandel, Bryan R Haugen, Kenneth D Burman, Zubair W Baloch, Ricardo V Lloyd, Raja R Seethala, William E Gooding, Simion I Chiosea, Cristiane Gomes-Lima, Robert L Ferris, Jessica M Folek, Raheela A Khawaja, Priya Kundra, Kwok Seng Loh, Carrie B Marshall, Sarah Mayson, Kelly L McCoy, Min En Nga, Kee Yuan Ngiam, Marina N Nikiforova, Jennifer L Poehls, Matthew D Ringel, Huaitao Yang, Linwah Yip, Yuri E Nikiforov
发表日期
2019/2/1
期刊
JAMA oncology
卷号
5
期号
2
页码范围
204-212
出版商
American Medical Association
简介
Importance
Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can be avoided for these patients if the nodules are reliably diagnosed as benign without surgery.
Objective
To determine the diagnostic accuracy of a multigene classifier (GC) test (ThyroSeq v3) for cytologically indeterminate thyroid nodules.
Design, Setting, and Participants
Prospective, blinded cohort study conducted at 10 medical centers, with 782 patients with 1013 nodules enrolled. Eligibility criteria were met in 256 patients with 286 nodules; central pathology review was performed on 274 nodules.
Interventions
A total of 286 FNA samples from thyroid nodules underwent molecular analysis using the multigene GC (ThyroSeq v3).
Main Outcomes and Measures
The primary outcome was diagnostic accuracy of the test for thyroid nodules …
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DL Steward, SE Carty, RS Sippel, SP Yang, JA Sosa… - JAMA oncology, 2019