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The aim of this study was to compare the effects of high-intensity aerobic interval and repeated-sprint ability (RSA) training on aerobic and anaerobic physiological variables in male football players. Forty-two participants were randomly assigned to either the interval training group (ITG, 4× 4 min running at 90–95% of HR max; n= 21) or repeated-sprint training group (RSG, 3× 6 maximal shuttle sprints of 40 m; n= 21). The following outcomes were measured at baseline and after 7 weeks of training: maximum oxygen uptake, respiratory compensation point, football-specific endurance (Yo-Yo Intermittent Recovery Test, YYIRT), 10-m sprint time, jump height and power, and RSA. Significant group× time interaction was found for YYIRT (p= 0.003) with RSG showing greater improvement (from 1917±439 to 2455±488 m) than ITG (from 1846±329 to 2077±300 m). Similarly, a significant interaction was found in RSA mean …