作者
Ping Wang, Renpeng Liu, Xiaojun Wu, Hongjuan Ma, Xiaoping Cao, Ping Zhou, Jiangye Zhang, Xiaocheng Weng, Xiao-Lian Zhang, Jun Qi, Xiang Zhou, Linhong Weng
发表日期
2003/2/5
期刊
Journal of the American Chemical Society
卷号
125
期号
5
页码范围
1116-1117
出版商
American Chemical Society
简介
Water-soluble DNA cross-linking phenol and biphenol derivatives 3 and 6 have been synthesized by a Mannich reaction. Both of them can cross-link DNA by photoactivation using visible light (wavelength > 400 nm). Compound 6 can cross-link DNA at pH 5.0 and 7.7, whereas no cross-link was observed at pH 10.0. Density functional theory (DFT) calculation indicated that 6 displays a twist structure. Therefore, it could bind to DNA naturally and has potent property to cross-link DNA after photoactivation.
引用总数
学术搜索中的文章
P Wang, R Liu, X Wu, H Ma, X Cao, P Zhou, J Zhang… - Journal of the American Chemical Society, 2003