作者
Saleh Eifan, Esther Schnettler, Isabelle Dietrich, Alain Kohl, Anne-Lie Blomström
发表日期
2013/10/4
来源
Viruses
卷号
5
期号
10
页码范围
2447-2468
出版商
Multidisciplinary Digital Publishing Institute
简介
Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.
学术搜索中的文章
S Eifan, E Schnettler, I Dietrich, A Kohl, AL Blomström - Viruses, 2013