作者
Andrés Esteban, Fernando Frutos-Vivar, Alfonso Muriel, Niall D Ferguson, Oscar Peñuelas, Victor Abraira, Konstantinos Raymondos, Fernando Rios, Nicolas Nin, Carlos Apezteguía, Damian A Violi, Arnaud W Thille, Laurent Brochard, Marco González, Asisclo J Villagomez, Javier Hurtado, Andrew R Davies, Bin Du, Salvatore M Maggiore, Paolo Pelosi, Luis Soto, Vinko Tomicic, Gabriel D’Empaire, Dimitrios Matamis, Fekri Abroug, Rui P Moreno, Marco Antonio Soares, Yaseen Arabi, Freddy Sandi, Manuel Jibaja, Pravin Amin, Younsuck Koh, Michael A Kuiper, Hans-Henrik Bülow, Amine Ali Zeggwagh, Antonio Anzueto
发表日期
2013/7/15
期刊
American journal of respiratory and critical care medicine
卷号
188
期号
2
页码范围
220-230
出版商
American Thoracic Society
简介
Rationale: Baseline characteristics and management have changed over time in patients requiring mechanical ventilation; however, the impact of these changes on patient outcomes is unclear.
Objectives: To estimate whether mortality in mechanically ventilated patients has changed over time.
Methods: Prospective cohort studies conducted in 1998, 2004, and 2010, including patients receiving mechanical ventilation for more than 12 hours in a 1-month period, from 927 units in 40 countries. To examine effects over time on mortality in intensive care units, we performed generalized estimating equation models.
Measurements and Main Results: We included 18,302 patients. The reasons for initiating mechanical ventilation varied significantly among cohorts. Ventilatory management changed over time (P < 0.001), with increased use of noninvasive positive-pressure ventilation (5% in 1998 to 14% in 2010), a decrease …
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A Esteban, F Frutos-Vivar, A Muriel, ND Ferguson… - American journal of respiratory and critical care …, 2013