作者
Erik Westhall, Andrea O Rossetti, Anne-Fleur van Rootselaar, Troels Wesenberg Kjaer, Janneke Horn, Susann Ullén, Hans Friberg, Niklas Nielsen, Ingmar Rosén, Anders Åneman, David Erlinge, Yvan Gasche, Christian Hassager, Jan Hovdenes, Jesper Kjaergaard, Michael Kuiper, Tommaso Pellis, Pascal Stammet, Michael Wanscher, Jørn Wetterslev, Matt P Wise, Tobias Cronberg, TTM-Trial Investigators, Manoj Saxena, Jennene Miller, Deborah Inskip, Lewis Macken, Simon Finfer, Noel Eatough, Naomi Hammond, Frances Bass, Elizabeth Yarad, Anne O'Connor, Simon Bird, Timothy Jewell, Gareth Davies, Karl Ng, Sharon Coward, Anders Åneman, Antony Stewart, Sharon Micallef, Sharyn Parker, Dennis Cortado, Sharon Micallef, Ann Gould, Meg Harward, Kelly Thompson, Naomi Hammond, Parisa Glass, John Myburgh, Ondrej Smid, Jan Belholavek, Marketa Kreckova, Ales Kral, Jan Horak, Michal Otahal, Jan Rulisek, Jan Malik, Martin Prettl, Jesper Kjaergaard, Christian Hassager, Michael Wascher, Soeren Boesgaard, Jacob E Moller, John Bro-Jeppesen, Ane Loof Johansen, Vincenzo Campanile, Alberto Peratoner, Francesca Verginella, Daniele Leone, Thomas Pellis, Andrea Roncarati, Eliana Franceschino, Anna Sanzani, Alice Martini, Micol Perlin, Paolo Pelosi, Iole Brunetti, Angelo Insorsi, Stefano Pezzato, Giorgio De Luca, Emanuela Gazzano, Gian Andrea Ottonello, Andrea Furgani, Rosanna Telani, Simona Maiani, Pascal Stammet, Christophe Werer, Jaqueline Kieffer, Janneke Horn, Annelou L vd Veen, Tineke Winters, Nicole P Juffermans, Michael Kuiper, PH Egbers, EC Boerma, RT Gerritsen, H Buter, C de Jager, F de Lange, M Loos, PM Koetsier, WP Kingma, N Bruins, L de Kock, M Koopmans, Frank Bosch, Monique AM Raaijmakers, SWL Metz-Hermans, Henrik Endeman, Saskia Rijkenberg, Addy Bianchi, Jan Hovdenes, Jan Frederik Bugge, Hilde Norum, Andreas Espinoza, Viesturs Kerans, Helene Brevik, Morten Svalebjørg, Guro Grindheim, Arne Jan Petersen, Andreas Baratt-Due, Jon Henrik Laake, Ulrik Spreng, Marte Marie Wallander Karlsen, Jørund Langøren, Rune Fanebust, Marianne Sætrang Holm, Stine Iren Flinterud, Carsten Wickman, Jesper Johnsson, Florian Ebner, Nerida Gustavsson, Heléne Petersson, Jörgen Petersson, Faezheh Nasiri, Frida Stafilidou, Kristine Edqvist, Sven Uhlig, Gunilla Sköld, Johan Sanner, Jesper Wallskog, Nicholas Wyon, Martin Golster, Anders Samuelsson, Carl Hildebrand, Taichi Kadowaki, Jessica Larsson-Viksten, Lina De Geer, Patrik Hansson
发表日期
2016/4/19
期刊
Neurology
卷号
86
期号
16
页码范围
1482-1490
出版商
Lippincott Williams & Wilkins
简介
Objective
To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by the American Clinical Neurophysiology Society.
Methods
In this cohort study, 4 EEG specialists, blinded to outcome, evaluated prospectively recorded EEGs in the Target Temperature Management trial (TTM trial) that randomized patients to 33°C vs 36°C. Routine EEG was performed in patients still comatose after rewarming. EEGs were classified into highly malignant (suppression, suppression with periodic discharges, burst-suppression), malignant (periodic or rhythmic patterns, pathological or nonreactive background), and benign EEG (absence of malignant features). Poor outcome was defined as best Cerebral Performance Category score 3–5 until 180 days.
Results
Eight TTM sites randomized 202 patients. EEGs were …
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