作者
Aline Bouwes, Jan M Binnekade, Michael A Kuiper, Frank H Bosch, Durk F Zandstra, Arnoud C Toornvliet, Hazra S Biemond, Bas M Kors, Johannes HTM Koelman, Marcel M Verbeek, Henry C Weinstein, Albert Hijdra, Janneke Horn
发表日期
2012/2
期刊
Annals of neurology
卷号
71
期号
2
页码范围
206-212
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
This study was designed to establish the reliability of neurologic examination, neuron‐specific enolase (NSE), and median nerve somatosensory‐evoked potentials (SEPs) to predict poor outcome in patients treated with mild hypothermia after cardiopulmonary resuscitation (CPR).
Methods
This multicenter prospective cohort study included adult comatose patients admitted to the intensive care unit (ICU) after CPR and treated with hypothermia (32–34°C). False‐positive rates (FPRs 1 − specificity) with their 95% confidence intervals (CIs) were calculated for pupillary light responses, corneal reflexes, and motor scores 72 hours after CPR; NSE levels at admission, 12 hours after reaching target temperature, and 36 hours and 48 hours after collapse; and SEPs during hypothermia and after rewarming. The primary outcome was poor outcome, defined as death, vegetative state, or severe disability (Glasgow …
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A Bouwes, JM Binnekade, MA Kuiper, FH Bosch… - Annals of neurology, 2012