作者
David J Clark, Saravana M Dhanasekaran, Francesca Petralia, Jianbo Pan, Xiaoyu Song, Yingwei Hu, Felipe da Veiga Leprevost, Boris Reva, Tung-Shing M Lih, Hui-Yin Chang, Weiping Ma, Chen Huang, Christopher J Ricketts, Lijun Chen, Azra Krek, Yize Li, Dmitry Rykunov, Qing Kay Li, Lin S Chen, Umut Ozbek, Suhas Vasaikar, Yige Wu, Seungyeul Yoo, Shrabanti Chowdhury, Matthew A Wyczalkowski, Jiayi Ji, Michael Schnaubelt, Andy Kong, Sunantha Sethuraman, Dmitry M Avtonomov, Minghui Ao, Antonio Colaprico, Song Cao, Kyung-Cho Cho, Selim Kalayci, Shiyong Ma, Wenke Liu, Kelly Ruggles, Anna Calinawan, Zeynep H Gümüş, Daniel Geiszler, Emily Kawaler, Guo Ci Teo, Bo Wen, Yuping Zhang, Sarah Keegan, Kai Li, Feng Chen, Nathan Edwards, Phillip M Pierorazio, Xi Steven Chen, Christian P Pavlovich, A Ari Hakimi, Gabriel Brominski, James J Hsieh, Andrzej Antczak, Tatiana Omelchenko, Jan Lubinski, Maciej Wiznerowicz, W Marston Linehan, Christopher R Kinsinger, Mathangi Thiagarajan, Emily S Boja, Mehdi Mesri, Tara Hiltke, Ana I Robles, Henry Rodriguez, Jiang Qian, David Fenyö, Bing Zhang, Li Ding, Eric Schadt, Arul M Chinnaiyan, Zhen Zhang, Gilbert S Omenn, Marcin Cieslik, Daniel W Chan, Alexey I Nesvizhskii, Pei Wang, Hui Zhang, Abdul Samad Hashimi, Alexander R Pico, Alla Karpova, Alyssa Charamut, Amanda G Paulovich, Amy M Perou, Anna Malovannaya, Annette Marrero-Oliveras, Anupriya Agarwal, Barbara Hindenach, Barbara Pruetz, Beom-Jun Kim, Brian J Druker, Chelsea J Newton, Chet Birger, Corbin D Jones, Cristina Tognon, DR Mani, Dana R Valley, Daniel C Rohrer, Daniel C Zhou, Darlene Tansil, David Chesla, David Heiman, David Wheeler, Donghui Tan, Doug Chan, Emek Demir, Ewa Malc, Francesmary Modugno, Gaddy Getz, Galen Hostetter, George D Wilson, Gerald W Hart, Heng Zhu, Hongwei Liu, Houston Culpepper, Hua Sun, Hua Zhou, Jacob Day, James Suh, Jasmine Huang, Jason McDermott, Jeffrey R Whiteaker, Jeffrey W Tyner, Jennifer Eschbacher, Jin Chen, John McGee, Jun Zhu, Karen A Ketchum, Karin D Rodland, Karl Clauser, Karna Robinson, Karsten Krug, Katherine A Hoadley, Ki Sung Um, Kim Elburn, Kimberly Holloway, Liang-Bo Wang, Lili Blumenberg, Linda Hannick, Liqun Qi, Lori J Sokoll, MacIntosh Cornwell, Marc Loriaux, Marcin J Domagalski, Marina A Gritsenko, Matthew Anderson, Matthew E Monroe, Matthew J Ellis
发表日期
2019/10/31
期刊
Cell
卷号
179
期号
4
页码范围
964-983. e31
出版商
Elsevier
简介
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC and paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration of proteogenomic measurements uniquely identified protein dysregulation of cellular mechanisms impacted by genomic alterations, including oxidative phosphorylation-related metabolism, protein translation processes, and phospho-signaling modules. To assess the degree of immune infiltration in individual tumors, we identified microenvironment cell signatures that delineated four immune-based ccRCC subtypes characterized by distinct cellular pathways. This study reports a large-scale proteogenomic analysis of …
学术搜索中的文章
DJ Clark, SM Dhanasekaran, F Petralia, J Pan, X Song… - Cell, 2019